Author's response to reviews Title:DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability Authors:
نویسندگان
چکیده
Yuta Muto ([email protected]) Takafumi Maeda ([email protected]) Koichi Suzuki ([email protected]) Takaharu Kato ([email protected]) Fumiaki Watanabe ([email protected]) Hidenori Kamiyama ([email protected]) Masaaki Saito ([email protected]) Kei Koizumi ([email protected]) Yuichiro Miyaki ([email protected]) Fumio Konishi ([email protected]) Sergio Alonso ([email protected]) Manuel Perucho ([email protected]) Toshiki Rikiyama ([email protected])
منابع مشابه
Update on the serrated pathway to colorectal carcinoma.
Adenocarcinoma of the large intestine can no longer be considered one disease but rather a family of diseases with different precursor lesions, different molecular pathways, and different end-stage carcinomas with varying prognoses. Approximately 60% of colorectal carcinomas arise from conventional adenomas via the suppressor pathway leading to microsatellite stable carcinomas. These carcinomas...
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Author's response to reviews: Same file as response to reviewer.
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AIMS To define the occurrence of KRAS and BRAF mutations, microsatellite instability (MSI), and MGMT and hMLH1 methylation and expression in colorectal serrated adenocarcinoma. METHODS AND RESULTS KRAS codon 12/13 and 59/61 and BRAF V600E mutations, MSI, and MGMT and hMLH1 methylation and expression in 42 serrated adenocarcinomas and 17 serrated adenomas were compared with those in 59 non-ser...
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The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established. We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of ...
متن کاملDistinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway
The presence or absence of MLH1 methylation may critically affect the heterogeneity of colorectal carcinoma (CRC) with the CpG island methylator phenotype (CIMP). Here, we investigated the differential characteristics of CIMP-high (CIMP-H) CRCs according to MLH1 methylation status. To further confirm the MLH1-dependent features in CIMP-H CRC, an independent analysis was performed using data fro...
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