CALL FOR PAPERS Chronic Kidney Disease and Fibrosis Proximal tubule PPAR attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction
نویسندگان
چکیده
Shenyang Li, Nithya Mariappan, Judit Megyesi, Brian Shank, Krishnaswamy Kannan, Sue Theus, Peter M. Price, Jeremy S. Duffield, and Didier Portilla Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Division of Rheumatology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Central Arkansas Veterans Healthcare System, Little Rock, Arkansas; and Division of Nephrology, Departments of Internal Medicine and Pathology, Center for Lung Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington
منابع مشابه
Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
We examined the effects of increased expression of proximal tubule peroxisome proliferator-activated receptor (PPAR)α in a mouse model of renal fibrosis. After 5 days of unilateral ureteral obstruction (UUO), PPARα expression was significantly reduced in kidney tissue of wild-type mice but this downregulation was attenuated in proximal tubules of PPARα transgenic (Tg) mice. When compared with w...
متن کاملRenin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. The present study was performed to identify the function of NLRP3 in modulating renal injury and fibrosis and the ...
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Introduction & Objective: Comparative reductase inhibitors, such as simvastatin increase HDL-cholestrol and decrease serum triglyceride and cholesterol. It is widely recognized that statins have organ protective nature and most effective for organ damage progressing. Obstructive uropathy can be used to indicate any obstruction to urinary flow which causes a developing of hydronephrosis, tubul...
متن کاملSimultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy.
Proximal tubular injury and apoptosis are key mediators of the development of kidney fibrosis, a hallmark of chronic kidney disease. However, the molecular mechanism by which tubular apoptotic cell death leads to kidney fibrosis is poorly understood. In the present study, we tested the roles of Bcl-2-associated X (Bax) and Bcl-2 antagonist/killer (Bak), two crucial proteins involved in intrinsi...
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