Biol. Pharm. Bull. 28(12) 2268—2270 (2005)

body, being contained in infusion solutions not only cause infusion-related phlebitis but also have been suggested to damage various organs such as the lungs, brain, kidneys, liver, and spleen. However, in Asian countries such as Japan, adequate attention is not paid to particulate contamination of parenteral solutions. For example, many drugs in glass ampoules are added to parenteral nutrition solutions, and preuse filtration is rarely performed in the preparation of parenteral nutrition solutions in the dispensary or ward. In addition, many medical institutions do not use in-line filters at the time of administration of admixed parenteral nutrition solutions. One of the reasons for the lack of adequate attention to particulate contamination of parenteral solutions may be poor recognition of this contamination because of only a few previous studies on in-use admixed parenteral nutrition solutions. Therefore, we evaluated particulate contamination of in-use admixed parenteral nutrition solutions and also microbial contamination of these solutions.