CALL FOR PAPERS STIM and Orai Proteins in Calcium Signaling Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype
نویسندگان
چکیده
Ruby A. Fernandez, Jun Wan, Shanshan Song, Kimberly A. Smith, Yali Gu, Mohammad Tauseef, Haiyang Tang, Ayako Makino, Dolly Mehta, and Jason X.-J. Yuan Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois; Department of Medicine, University of Illinois at Chicago, Chicago, Ilinois; Division of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine, Tucson, Arizona; and Department of Physiology, The University of Arizona College of Medicine, Tucson, Arizona
منابع مشابه
Orai channel-mediated Ca signals in vascular and airway smooth muscle
Spinelli AM, Trebak M. Orai channel-mediated Ca signals in vascular and airway smooth muscle. Am J Physiol Cell Physiol 310: C402–C413, 2016. doi:10.1152/ajpcell.00355.2015.—Orai (Orai1, Orai2, and Orai3) proteins form a family of highly Ca -selective plasma membrane channels that are regulated by stromal-interacting molecules (STIM1 and STIM2); STIM proteins are Ca sensors located in the membr...
متن کاملOrai channel-mediated Ca2+ signals in vascular and airway smooth muscle.
Orai (Orai1, Orai2, and Orai3) proteins form a family of highly Ca(2+)-selective plasma membrane channels that are regulated by stromal-interacting molecules (STIM1 and STIM2); STIM proteins are Ca(2+) sensors located in the membrane of the endoplasmic reticulum. STIM and Orai proteins are expressed in vascular and airway smooth muscle and constitute the molecular components of the ubiquitous s...
متن کاملSTIM and ORAI proteins in the nervous system.
Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the endoplasmic reticulum. Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3. The resulting store-operated calcium entry (SOCE), mostly controlled by the principal com...
متن کاملReference Redox modulation of STIM - ORAI signaling BHARDWAJ , Rajesh , HEDIGER , Matthias A , DEMAUREX , Nicolas
STIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry pathway and loss of function in these proteins is associated with severe immune and muscular disorders. Other isoforms-STIM1L, STIM2, ORAI2 and ORAI3 exhibit varied expression levels in different cell types along with several other interaction partners and thereby play different roles to facilitate, reg...
متن کاملStim and Orai proteins in neuronal Ca2+ signaling and excitability
Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca(2+) release-activated Ca(2+) (CRAC) current (ICRAC) and store-operated Ca(2+) entry (SOCE) only in non-excitable cells. SOCE is activated following the depletion of the endogenous Ca(2+) stores, which are mainly located within the endoplasmic reticulum (ER), to replete the intracellular Ca(2+) reservoir and engage s...
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