Localisation of the MRX 3 gene for non - specific X linked mental
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چکیده
Abstiract A family is described with five affected males segregating a new gene for non-specific X linked mental retardation (MRX). Linkage analysis localised the gene at Xq28-qter. The maximum lod score was 2-89 with DXS52 (Stl4) at 0=0 0. A recombinant was observed with DXS304 (U6.2) defining the proximal limit to the localisation. No evidence for linkage was determined using markers at several points along the remainder of the X chromosome, including the regions known to contain MRXJ and MRX2. This delineates the third gene for non-specific X linked mental retardation, MRX3.
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تاریخ انتشار 2004