Analysis of the HIV resistance related HLA dRB1 restricted CD4+ T cell epitopes among Indian HIV patients
نویسندگان
چکیده
Background Host genetic factors are the major determining factor for variation in response to HIV infection and are related to resistance among HIV patients. HLA dRB1*1501, DRB1*1502, DRB1*1301, DRB1*1302, DRB1*1101-05 are widely reported alleles associated with low viraemia in infected individuals. Computational predictions have made it possible to identify potentially strong peptide binders to HLA molecules that so that can be then tested in vitro and in vivo as putative epitopes for peptide based vaccines. The present study investigated the consequences of sequence variations within HLA dRB1 alleles in selecting the epitopes and their interactions.
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