Immunodetection of oligoclonal bands in serum and CSF of Multiple Sclerosis patients

1 Hospital Universitari i Politècnic La Fe, València, Spain 2 Department of Functional Biology, University of Valencia, Valencia, Spain 3 Department of Biochemistry and Molecular Biology, University of Valencia, and INCLIVA Biomedical Research Institute, Valencia, Spain 4 Multiple Sclerosis Laboratory, Department of Biomedicine, Prince Felipe Research Center, Valencia, Spain Figure 1: Immunodetection of oligoclonal bands in serum and CSF of Multiple Sclerosis patients. Pattern 1: OCBs in CSF only (positive): Oligoclonal bands present in CSF only. Intrathecal IgG synthesis as seen in MS; Pattern 2: No OCBs seen (negative, policlonal): No oligoclonal bands in CSF or Serum. No intrathecal Ig synthesis; Pattern 3: Identical OCBs in both (mirror): Bands in serum mirror those in CSF. This suggests systemic Ig synthesis; Pattern 4: Identical OCBs in both with extra in CSF (more than): Identical bands in both serum and CSF with extra bands in CSF. Image demonstrates both intrathecal and systemic Ig synthesis. This is identical as it is seen in MS.