Neurobiology of Disease Altered Localization of GABAA Receptor Subunits on Dentate Granule Cell Dendrites Influences Tonic and Phasic Inhibition in a Mouse Model of Epilepsy
نویسندگان
چکیده
Nianhui Zhang,1 Weizheng Wei,2 Istvan Mody,2,3 and Carolyn R. Houser1,3,4 Departments of 1Neurobiology and 2Neurology and Physiology, and 3Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, and 4Research Service, Veterans Administration Greater Los Angeles Healthcare System, West Los Angeles, Los Angeles, California 90073
منابع مشابه
Neurobiology of Disease Trafficking of GABAA Receptors, Loss of Inhibition, and a Mechanism for Pharmacoresistance in Status Epilepticus
During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithiumpilocarpine-induced SE, our studies of postsynaptic GABAA receptors in dentate gyrus granule cells show a reduction in the amplitude of miniature IPSCs (mIPSCs). Anatomical studies show a reduction in the colocalization of the 2/ 3 and 2 subunits of GABAA receptors ...
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