LYMPHOID NEOPLASIA Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes
نویسندگان
چکیده
1Inserm U917, Université Rennes 1, Etablissement Français du sang, Bretagne, France; 2Pôle Cellules & Tissus, Centre Hospitalier Universitaire (CHU) Pontchaillou, Rennes, France; 3Institut de Recherche en Biothérapie, Hôpital Saint-Eloi, CHU Montpellier, Montpellier, France; 4Inserm U936, Université de Rennes 1, Bretagne, France; 5Service d’Hématologie Clinique, CHU Pontchaillou, Rennes, France; and 6Service de Chirurgie Thoracique et Cardiovasculaire, CHU Pontchaillou, Rennes, France
منابع مشابه
Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes.
Accumulating evidence indicates that infiltrating stromal cells contribute directly and indirectly to tumor growth in a wide range of cancers. In follicular lymphoma (FL), malignant B cells are found admixed with heterogeneous lymphoid-like stromal cells within invaded lymph nodes and BM. In addition, mesenchymal stromal cells (MSCs) support in vitro FL B-cell survival, in particular after thei...
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