Secretory IgA in protein-calorie malnutrition.
نویسندگان
چکیده
The secretory IgA system was investigated in children with protein-calorie malnutrition (PCM). The results of the study indicated that in children suffering from kwashiorkor and marasmus the concentration of IgA in duodenal fluid, saliva, nasal secretions, and tears was significantly reduced on admission and returned to normal 4 weeks after treatment. However, the concentration of secretory IgA in children with mild to moderate PCM was similar to that of normal children. Secretory IgA deficiency may be an important factor in promoting bacterial growth and this may account for the increased incidence and severity of mucosal infections in children with severe PCM.
منابع مشابه
Immunoglobulin-containing cells in jejunal mucosa of children with protein-energy malnutrition and gastroenteritis.
Jejunal biopsies from 20 well nourished children (average age 12.8 months) with gastroenteritis, and 20 children (average age 20 months) with protein-energy malnutrition were examined by immunofluorescent technique for immunoglobulins A, G, M, E, and D, and for epithelial glycoprotein secretory component. Compared with previous studies on normal infants, the children with gastroenteritis showed...
متن کاملBiochemical and Molecular Roles of Nutrients Reduction in the Quantity of the Polymeric Immunoglobulin Receptor Is Sufficient to Account for the Low Concentration of Intestinal Secretory Immunoglobulin A in a Weanling Mouse Model of Wasting Protein-Energy Malnutrition
The main objective of this investigation was to determine the influence of protein-energy malnutrition (PEM) in weanling mice on the expression of the hepatic and intestinal polymeric immunoglobulin receptor (pIgR), a molecule that transports mucosal immunoglobulin A (IgA) into the intestinal lumen. An experimental system was used that produces systemic wasting (loss of approximately 1.9% of in...
متن کاملEvaluation of Nutritional Status in a Teaching Hospital Neonatal Intensive Care Unit
Background:Extrauterine growth restriction remains a common and serious problem in newborns especially who are small, immature, and critically ill. Very low birth weight infants (VLBW) had 97% and 40% growth failure at 36 weeks and 18-22 months post-conceptual age respectively. The postnatal development of premature infants is critically dependent on an adequate nutritional intake that mimics a...
متن کاملProtein Calorie Malnutrition and Immune Response in Children
The fundamental relationship between malnutrition and immunity was initially described as a thymolymphatic deficiency caused by protein calorie malnutrition (PCM). The selective sensitivity of the thymus to nutritional injury is specifically important in the formative phases of the fetal and neonatal immune system. Recent studies suggest that prenatal nutrition and growth during the first of li...
متن کاملEffect of calorie supplementation on growth of undernourished childre & international nutrition
It has been generally believed that the major reason for the widespread malnutrition and growth retardation in early childhood in many countries in the world is the existence of a “protein gap” in the diets of children in these countries. There has been overwhelming emphasis on protein deficiency as the major factor concerned in childhood malnutrition. Though the term “protein-calorie malnutrit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 51 11 شماره
صفحات -
تاریخ انتشار 1976