Reactions to Total Dose Intravenous Infusion of Iron Dextran (imferon).

Total dose imferon (iron-dextran complex) infusion therapy in severe hookworm anaemia.

Effect of intravenous iron-dextran (Imferon) infusion on antigen induced monarticular arthritis in rabbits.

The effect of intravenously infused iron-dextran (Imferon) on the progression of antigen induced monarticular arthritis in rabbits was studied. A rapid deposition of iron and apoferritin in the synovia of arthritis joints occurred after infusion of iron-dextran during either the acute or chronic phases of the disease. This coincided with the appearance of catalytic (bleomycin reactive) iron in ...

The Treatment of Iron-deficiency Anemia with Intravenous Iron Dextran.

I N THE THERAPY of iron-deficiency anemia, iron given orally is safe, effective, inexpensive, and is usually the treatment of choice, but occasionally when a rapid replenishment of iron stores is desired, administration by the parenteral route is indicated. Heath, Strauss and Castle,1 in 1938, showed that when 16-32 mg. of iron as ferric ammonium citrate is injected subcutaneously or intramuscu...

Structure, chemistry, and pharmacokinetics of intravenous iron agents.

Structure and Chemistry All intravenous (IV) iron agents are colloids that consist of spheroidal iron-carbohydrate nanoparticles. At the core of each particle is an iron-oxyhydroxide gel. The core is surrounded by a shell of carbohydrate that stabilizes the iron-oxyhydroxide, slows the release of bioactive iron, and maintains the resulting particles in colloidal suspension. IV iron agents share...

Parenteral iron dextran therapy.

Parenteral iron therapy is indicated in patients with iron-deficiency anemia associated with conditions that interfere with the ingestion or absorption of oral iron. Replacement doses of iron required to replenish iron stores are based on body weight and the observed hemoglobin value. Methods of administering iron dextran are reviewed, including intramuscular and intravenous injections of the u...