Communication Interaction of class A G protein-coupled receptors with G proteins
نویسندگان
چکیده
A model for interaction of class A G protein-coupled receptor with the G protein G subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gt C-terminal peptide bound to RD* while stabilizing it. Assuming the interactions involve conserved parts of the partners, the model specifies the conserved Helix 2 non-polar X-X, Helix 3 DRY and Helix 7/8 NP-YF RD* motifs interacting with the Gt C-terminal peptide, in compliance with the structure of the latter. A concomitant role of Gt and Gt C-termini in stabilizing RD* could possibly be resolved assuming a receptor dimer as requisite for G protein activation.
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