A clinical comparison of purified bovine and purified porcine insulins.

Paradoxical lipodystrophic changes due to conventional bovine and highly purified porcine/bovine insulins.

A 78-year-old woman developed marked insulin lipoatrophy due to conventional bovine insulin injected into the upper limbs. Changing to a combination of highly purified porcine/bovine insulins injected into the lower limbs resulted in the opposite effect, namely insulin-induced lipohypertrophy. Use was then made of this effect by injecting the highly purified insulins into the atrophied upper li...

Development of IgE antibodies to human (recombinant DNA), porcine, and bovine insulins in diabetic subjects.

Thirty-one previously untreated diabetic individuals received only human insulin (recombinant DNA) for 1 yr with no adverse reactions. The development of serum IgE antibodies to human, porcine, and bovine insulins was assessed by a sepharose radioallergoabsorbent test (RAST). Immunoglobulin (total Ig antibody) binding was assessed by a nonabsorbed species-specific radioimmunoassay. During thera...

Lipohypertrophy and lipoatrophy complicating treatment with highly purified bovine and porcine insulins.

Lipoatrophy and lipohypertrophy were the most frequently reported local complications of conventional insulin therapy. Early reports following the introduction of highly purified insulins suggested a reduction in the frequency of lipohypertrophy and lipoatrophy. Since highly purified insulins have been in common usage for 10 years, the present frequency of these complications was assessed in a ...

Immunogenicity of insulin.

Highly purified bovine and porcine insulins (single component insulin) did not produce antibodies in rabbits, and the highly purified porcine insulin was less immunogenic in diabetic patients than USP porcine insulin. In rabbits one porcine high molecular weight fraction (peak A) and two bovine high molecular weight fractions (peak A and peak B) separated from USP insulin by Sephadex chromatogr...

Allergy to purified bovine, porcine, and human insulins.