Haematological Manifestations in Systemic Lupus Erythematosus
نویسندگان
چکیده
Systemic lupus erythematosus (SLE) is the most common multisystem connective tissue disease. It is characterised by a wide variety of clinical features and presence of numerous auto-antibodies, circulating immune complexes and widespread immunologically determined tissue damage [1]. Hematological abnormalities are common in SLE. All the cellular elements of the blood & coagulation pathway can be affected in SLE patients. The major hematological manifestations of SLE are anemia, leucopenia, thrombocytopenia, and antiphospholipid syndrome (APS). Hematological abnormalities in patients with this disease require careful long-term monitoring and prompt therapeutic intervention. Throughout the chapter we will analyze each abnormality, enumerate and explain the causes of each one and discuss an approach to the management.
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