CALL FOR PAPERS Pathophysiology of Acute Kidney Injury Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta
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چکیده
Mauricio M. Sendeski, Anja Bondke Persson, Zhi Zhao Liu, Jonas F. Busch, Steffen Weikert, Pontus B. Persson, Stefan Hippenstiel, and Andreas Patzak Institut fuer Vegetative Physiologie, Charite Universitaetzsmedizin-Berlin, Berlin, Germany; Klinik fuer Urologie, Charite Universitaetsmedizin-Berlin, Berlin, Germany; and Medizinische Klinik m.S. Infektiologie und Pulmologie, Charite Universitaetsmedizin-Berlin, Berlin, Germany
منابع مشابه
Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta.
Contrast-induced acute kidney injury is an important clinical event with a worldwide increasing number of cases. Medullary hypoperfusion and hypoxia due to constriction of vasa recta are main factors in the pathophysiology of acute kidney injury. However, the mechanism of contrast media (CM)-induced vessel constriction is not known. We tested the hypothesis that vasa recta constriction is a con...
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An important side effect of diagnostic contrast drugs is contrast-induced acute kidney injury (CI-AKI; a sudden decrease in renal function) occurring 48-72 hours after injection of a contrast drug that cannot be attributed to other causes. Its existence has recently been challenged, because of some retrospective studies in which the incidence of AKI was not different between subjects who receiv...
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THE ROLE OF THE ENDOTHELIUM in the adverse reaction of blood vessels to contrast media imaging agents, and in particular the sensitivity of the kidney, has been a subject of interest dating back to 1964 (2). The renal vasculature seems particularly sensitive to the influence of endothelium-derived nitric oxide vasodilation (7) and its buffering of endogenous vasoconstrictors. Thus the possible ...
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It is well known that iodinated radiographic contrast media may cause kidney dysfunction, particularly in patients with preexisting renal impairment associated with diabetes. This dysfunction, when severe, will cause acute renal failure (ARF). We may define contrast-induced Acute Kidney Injury (AKI) as ARF occurring within 24-72 hrs after the intravascular injection of iodinated radiographic co...
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تاریخ انتشار 2012