Cadherin-11 Provides Specific Cellular Adhesion between Fibroblast-like Synoviocytes

Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion

Specific adhesion among like cells is a key determinant of the architecture of tissues. Homophilic (like binds like) adhesive interactions between cells are mediated by cadherins. These integral membrane glycoproteins have a crucial role in tissue morphogenesis during development and the maintenance of tissue integrity in adults. There is also an increasing recognition of a regulatory role for ...

Secretion of Placental Growth Factor Promotes Angiogenesis by Enhanced Fibroblast-like Synoviocytes via Cadherin-11 Interaction of Mesenchymal Stem Cells with

Why does rheumatoid arthritis involve the joints?

A long-standing question in rheumatology is why inflammatory arthritides such as rheumatoid arthritis involve the joints. Many studies have addressed this question; a recent article by Lee et al.1 provides a new answer that is both obvious and intriguing. Rheumatoid arthritis affects the joints because of the essential role of the synovium in regulating inflammation. The normal synovial membran...

Correlation between expression of CD44 splice variant v8-v9 and invasiveness of fibroblast-like synoviocytes in an in vitro system.

OBJECTIVES Rheumatoid arthritis is characterized by inflammation, hyperplasia of the synovial membrane, pannus formation and degradation of cartilage and bone. Fibroblast-like synoviocytes are thought to be involved in the invasion and subsequent degradation of cartilage. Two processes play a role in cellular invasion: cellular migration and degradation of the extracellular matrix. The adhesion...

Evaluation of tendon healing using fibroblast like synoviocytes in rabbits: A biomechanical study

Tendon never restores the complete biological and mechanical properties after healing. Several techniques are available for tissue-engineered biological augmentation for tendon healing like stem cells. Recently, synovium has been investigated as a source of cells for tissue engineering. In the present study, we investigated potentials of fibroblast like synoviocytes (FLSs) in tendon healing. Si...