Listeria monocytogenes triggers the cell surface expression of Gp96 and interacts with its N-terminus to support cellular infection
نویسندگان
چکیده
Background: Gp96 is the cellular receptor for Vip, a Listeria monocytogenes surface protein. The molecular details of Gp96-Vip interaction are unknown. Results: Cell surface expression of Gp96 increases upon Listeria infection. Gp96 Nterminal is required for Vip interaction. Conclusion: Gp96 N-terminal domain is exposed to the extracellular milieu and is required for optimal Listeria entry. Significance: Topological insights on Gp96 plasma membrane association.
منابع مشابه
Listeria monocytogenes triggers the cell surface expression of Gp96 protein and interacts with its N terminus to support cellular infection.
Listeria monocytogenes is an intracellular food-borne pathogen causing listeriosis in humans. This bacterium deploys an arsenal of virulence factors that act in concert to promote cellular infection. Bacterial surface proteins are of primary importance in the process of host cell invasion. They interact with host cellular receptors, inducing/modulating specific cellular responses. We previously...
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