A Ubiquitin-like Protein Unleashes Ubiquitin Ligases
نویسندگان
چکیده
Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.
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ورودعنوان ژورنال:
- Cell
دوره 135 شماره
صفحات -
تاریخ انتشار 2008