Why can't cytotoxic T cells handle HIV?
نویسندگان
چکیده
Conventional cytotoxic T lymphocytes (CTLs) that express the CD8 co-receptor alongside their clonally distributed receptor for antigen are superbly equipped to eliminate virus-infected cells. They recognize short peptide fragments of intracellular pathogens which are brought to the surface of the infected cell in the groove of the major histocompatibility complex (MHC)-encoded class I molecules (1). Once a resting CTL is induced to full effector function by appropriate stimulation with antigen-presenting cells, it can recognize and kill an infected target cell
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 92 13 شماره
صفحات -
تاریخ انتشار 1995