Annotation of Conserved Motifs in Drosophila
نویسنده
چکیده
Introduction The D. melanogaster Muller F element is unusual because it appears to be packaged as heterochromatin, but the genes that reside in this domain exhibit expression patterns that are similar to other euchromatic genes (RIDDLE et al. 2012). This dichotomy suggests that Muller F element genes either have some unique characteristics, or they have a more robust version of the gene activation machinery that enables them to function in a heterochromatic environment. For example, Muller F element genes might have distinct transcription factor binding sites (TFBS) near the transcription start sites (TSS) or they could simply have more enhancers around the TSS that facilitate the activation of a gene.
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