Enhanced Antioxidant Activities of Metal Conjugates of Curcumin Derivatives
نویسندگان
چکیده
Antioxidant properties of three Curcumin derivatives in which the 1,3-diketone system is appended with nitrogen and sulfur donors and their copper conjugates are examined for the first time. Metal conjugation seems to offer distinct advantages in radical scavenging activities of curcumin compounds.
منابع مشابه
Biol. Pharm. Bull. 30(1) 74—78 (2007)
various diseases including neurodegenerative diseases, myocardial ischemia-reperfusion injury and cancer. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5,dione], the principal yellow pigment isolated from turmeric (Curcuma longa Linn), is known as a potent antioxidant comparable to a-tocopherol. Its antioxidant activities have been studied in several in vitro models. Despite its...
متن کاملEvaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors.
Curcumin (diferuloylmethane) is the main active ingredient of turmeric, a traditional herbal medicine and food of south Asia. Curcumin has been found to have a wide range of biological activities, including antioxidant, anti-inflammatory, chemopreventive and chemotherapeutic activities. Curcumin is currently being tested in clinical trials for treatment of various types of cancers, including mu...
متن کاملAntioxidant and Hypoglycemic Effects of Curcumin Pyrazole Derivatives
Objective: To investigate the antioxidant properties of curcumin pyrazole derivatives using different in-vitro models and hypoglycemic potential by gluconeogenesis studies. Methods: Antioxidant ability of curcumin pyrazole derivatives was evaluated by using DPPH, nitric oxide, superoxide anion scavenging and lipid peroxidation assays comparing with standard, ascorbic acid (AA). The hypoglycemic...
متن کاملNeuroprotective Effects and Mechanisms of Curcumin–Cu(II) and –Zn(II) Complexes Systems and Their Pharmacological Implications
Alzheimer's disease (AD) is the main form of dementia and has a steadily increasing prevalence. As both oxidative stress and metal homeostasis are involved in the pathogenesis of AD, it would be interesting to develop a dual function agent, targeting the two factors. Curcumin, a natural compound isolated from the rhizome of Curcuma longa, is an antioxidant and can also chelate metal ions. Wheth...
متن کاملSynthesis of amino acid conjugates of tetrahydrocurcumin and evaluation of their antibacterial and anti-mutagenic properties.
Tetrahydrocurcumin (THC), the hydrogenated and stable form of curcumin, exhibits physiological and pharmacological activities similar to curcumin. A protocol has been developed for the synthesis of novel conjugates of THC with alanine (2a), isoleucine (2b), proline (2c), valine (2d), phenylalanine (2e), glycine (2f) and leucine (2g) in high yields (43-82%). All the derivatives of THC exhibited ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Metal-Based Drugs
دوره 8 شماره
صفحات -
تاریخ انتشار 2001