Liposome Fusion
نویسندگان
چکیده
Fusion of biological membranes is a fundamental process in many cellular functions, including the intracellular delivery of lipids, proteins, and metabolites by transport vesicles, endocytosis, exocytosis, cell division, cell-cell fusion, fertilization, and the invasion of cells by enveloped viruses. These complex fusion processes involve proteins that bring the fusing membranes into close proximity and promote fusion through membrane destabilization. While a number of fusion-promoting proteins have been characterized (White, 1992), the exact mechanism of the fusion events remain poorly defined. The use of liposomes as model biological membranes permits the study of membrane fusion as it relates to the lipid bilayer in relatively simple systems.
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