Clopidogrel induced arthritis and fever
نویسندگان
چکیده
Cheng-Fu CAO, Feng ZHANG, Hong Chen, Jun-Xian SONG, Chuan-Fen LIU, Su-Fang LI, Chong-You LEE Department of Cardiology, Peking University People’s Hospital, Beijing, China Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People’s Hospital, Beijing, China Center for Cardiovascular Translational Research, Peking University People’s Hospital, Beijing, China
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Clopidogrel-Induced Recurrent Polyarthritis
Clopidogrel is an oral thienopyridine and together with aspirin is a component of dual antiplatelet therapy for the prevention of stent thrombosis after intracoronary stent placement. The common adverse effects from its use are an increased risk of bleeding, neutropenia, and rash. Arthralgia and backache are also known to occur with its use. There have been case reports linking arthritis with t...
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The P2Y12 receptor plays a crucial role in the regulation of platelet activation by several agonists, which is irreversibly antagonized by the active metabolite of clopidogrel, a widely used anti-thrombotic drug. In this study, we investigated whether reduction of platelet reactivity leads to reduced inflammatory responses using a rat model of erosive arthritis. We evaluated the effect of clopi...
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