Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice.

نویسندگان

  • Peter Seiler
  • Michel Enderlin-Paput
  • Philippe Pfaff
  • Maria Weiss
  • Daniel Ritz
  • Martine Clozel
  • Hans H Locher
چکیده

The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of Clostridium difficile-associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent in vitro activity against C. difficile and against VRE and is currently in clinical development for the treatment of CDAD. We report that CDZ treatment did not lead to intestinal VRE overgrowth in mice.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 60 1  شماره 

صفحات  -

تاریخ انتشار 2016