Innovative Methodology Novel method for measuring effects of gas compression on expiratory flow

Sharafkhaneh, Amir, Todd M. Officer, Sheila GoodnightWhite, Joseph R. Rodarte, and Aladin M. Boriek. Novel method for measuring effects of gas compression on expiratory flow. Am J Physiol Regul Integr Comp Physiol 287: R479–R484, 2004. First published April 29, 2004; 10.1152/ajpregu.00573.2003.—During forced vital capacity maneuvers in subjects with expiratory flow limitation, lung volume decreases during expiration both by air flowing out of the lung (i.e., exhaled volume) and by compression of gas within the thorax. As a result, a flow-volume loop generated by using exhaled volume is not representative of the actual flow-volume relationship. We present a novel method to take into account the effects of gas compression on flow and volume in the first second of a forced expiratory maneuver (FEV1). In addition to oral and esophageal pressures, we measured flow and volume simultaneously using a volume-displacement plethysmograph and a pneumotachograph in normal subjects and patients with expiratory flow limitation. Expiratory flow vs. plethysmograph volume signals was used to generate a flow-volume loop. Specialized software was developed to estimate FEV1 corrected for gas compression (NFEV1). We measured reproducibility of NFEV1 in repeated maneuvers within the same session and over a 6-mo interval in patients with chronic obstructive pulmonary disease. Our results demonstrate that NFEV1 significantly correlated with FEV1, peak expiratory flow, lung expiratory resistance, and total lung capacity. During intrasession, maneuvers with the highest and lowest FEV1 showed significant statistical difference in mean FEV1 (P 0.005), whereas NFEV1 from the same maneuvers were not significantly different from each other (P 0.05). Furthermore, variability of NFEV1 measurements over 6 mo was 5%. We concluded that our method reliably measures the effect of gas compression on expiratory flow.