Antibacterial Activity of Zinc Oxide – Gentamicin Hybrid Material
نویسندگان
چکیده
Nanocrystalline ZnO particles were prepared from ethanolic solutions of zinc acetate by forced hydrolysis, at a low temperature. The fresh prepared ZnO nanoparticles were coated with gentamicin. The nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and thermal analysis (TG-DSC). The electronic (UV-Vis), infrared (FTIR) and photoluminescence (PL) spectra were also recorded. The biological activity tests such as minimum inhibitory concentration (MIC) and disk diffusion were performed in Mueller–Hinton broth using different concentrations of ZnO and ZnO-gentamicin hybrid nanoparticles, by a standard microbial method on Enterococcus faecalis, Salmonella, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Listeria monocytogenes. The bacteriological tests indicate a synergic activity of ZnO-gentamicin nanoparticles. The release rate of gentamicin was monitored photometrically with UV-Vis spectrometer.
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