A Role for Phasic Dopamine Neuron Firing in Habit Learning
نویسندگان
چکیده
In this issue of Neuron, Wang et al. (2011) show that mice with dopamine neuron-specific NMDAR1 deletion have attenuated phasic dopamine neuron firing and a deficit in habit learning. These findings indicate that brain regions sensitive to phasic dopamine signals may underlie habit learning.
منابع مشابه
Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior.
Midbrain dopamine (DA) neurons fire in 2 characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. However, the inability to selectively disrupt these patterns of activity has hampered the precise definition of the function of these modes of signaling. Here, we addressed the role of phasic DA in learning and other DA-dependent behaviors by attenuating D...
متن کاملDopamine, prediction error and associative learning: a model-based account.
The notion of prediction error has established itself at the heart of formal models of animal learning and current hypotheses of dopamine function. Several interpretations of prediction error have been offered, including the model-free reinforcement learning method known as temporal difference learning (TD), and the important Rescorla-Wagner (RW) learning rule. Here, we present a model-based ad...
متن کاملMethamphetamine produces bidirectional, concentration-dependent effects on dopamine neuron excitability and dopamine-mediated synaptic currents.
Amphetamine-like compounds are commonly used to enhance cognition and to treat attention deficit/hyperactivity disorder, but they also function as positive reinforcers and are self-administered at doses far exceeding clinical relevance. Many of these compounds (including methamphetamine) are substrates for dopamine reuptake transporters, elevating extracellular dopamine by inhibiting uptake and...
متن کاملAn exploration-exploitation model based on norepinepherine and dopamine activity
We propose a model by which dopamine (DA) and norepinepherine (NE) combine to alternate behavior between relatively exploratory and exploitative modes. The model is developed for a target detection task for which there is extant single neuron recording data available from locus coeruleus (LC) NE neurons. An exploration-exploitation trade-off is elicited by regularly switching which of the two s...
متن کاملExcitatory Neuromodulator Reduces Dopamine Release, Enhancing Prolactin Secretion
Hypothalamic dopamine neurons inhibit pituitary prolactin secretion. In this issue of Neuron, Lyons et al. provide evidence for a novel model, whereby the excitatory neuropeptide TRH depolarizes gap-junction-coupled dopamine neurons, leading to a shift in the population pattern of action potentials from phasic burst firing to regular tonic firing, hypothetically reducing dopamine release while ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 72 شماره
صفحات -
تاریخ انتشار 2011