In vitro and in vivo activities of E-101 solution against Acinetobacter baumannii isolates from U.S. military personnel.

نویسندگان

  • G A Denys
  • J C Davis
  • P D O'Hanley
  • J T Stephens
چکیده

We evaluated the in vitro and in vivo activity of a novel topical myeloperoxidase-mediated antimicrobial, E-101 solution, against 5 multidrug-resistant Acinetobacter baumannii isolates recovered from wounded American soldiers. Time-kill studies demonstrated rapid bactericidal activity against all A. baumannii strains tested in the presence of 3% blood. The in vitro bactericidal activity of E-101 solution against A. baumannii strains was confirmed in a full-thickness excision rat model. Additional in vivo studies appear warranted.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 55 7  شماره 

صفحات  -

تاریخ انتشار 2011