Wnt3a: functions and implications in cancer.

نویسندگان

  • Sha He
  • Yi Lu
  • Xia Liu
  • Xin Huang
  • Evan T Keller
  • Chao-Nan Qian
  • Jian Zhang
چکیده

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.

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عنوان ژورنال:
  • Chinese journal of cancer

دوره 34 12  شماره 

صفحات  -

تاریخ انتشار 2015