Imaging, Diagnosis, Prognosis A Replication Study and Genome-Wide Scan of Single-Nucleotide Polymorphisms Associated with Pancreatic Cancer Risk and Overall Survival
نویسندگان
چکیده
Purpose: To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS). ExperimentalDesign: The germ lineDNAof 531pancreatic cancer cases and305healthy controls froma hospital-based studywas genotyped at SNPs previously reported to be associatedwith pancreatic cancer risk or clinical outcome.We analyzedputative risk SNPs for replication of their reported effects on risk and tested for novel effects on OS. Similarly, we analyzed putative survival-associated SNPs for replication of their reported effects onOS and tested for novel effects on risk. Finally, we conducted a genome-wide association study (GWAS)ofOSusing a subset of 252 cases,with two subsequent validation sets of 261 and572patients,
منابع مشابه
A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival.
PURPOSE To explore the effects of single-nucleotide polymorphisms (SNP) on pancreatic cancer risk and overall survival (OS). EXPERIMENTAL DESIGN The germ line DNA of 531 pancreatic cancer cases and 305 healthy controls from a hospital-based study was genotyped at SNPs previously reported to be associated with pancreatic cancer risk or clinical outcome. We analyzed putative risk SNPs for repli...
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