Pursuing Cardiac Progenitors: Regeneration Redux

Pursuing Candidate Stem Cells for Optimal Cardiac Regeneration in Patients Suffered from Acute Coronary Syndrome

Cardiac muscle regeneration: lessons from development.

The adult human heart is an ideal target for regenerative intervention since it does not functionally restore itself after injury yet has a modest regenerative capacity that could be enhanced by innovative therapies. Adult cardiac cells with regenerative potential share gene expression signatures with early fetal progenitors that give rise to multiple cardiac cell types, suggesting that the evo...

P-74: Effect of Fndc5 Overexpression onCardiac Differentiation Rate of mESCs

Background: Fibronectin type III domain-containing 5 proteins (Fndc5), an exercise hormone, formerly known as peroxisomal protein that was cloned in 2002. Transcript profile analysis of Fndc5 revealed high degree of expression in heart, skeletal muscle and brain. Our recent studies indicated a significant increase (approximately 10 folds) in mRNA level of Fndc5 when mouse embryonic stem cells w...

Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells.

BACKGROUND The safety and efficacy of myocardial regeneration using embryonic stem cells are limited by the risk of teratoma and the high rate of cell death. METHODS AND RESULTS To address these issues, we developed a composite construct made of a sheet of adipose tissue-derived stroma cells and embryonic stem cell-derived cardiac progenitors. Ten Rhesus monkeys underwent a transient coronary...

S13-02 In vivo visualization of hematopoietic stem cell generation

The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unraveling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Previously, we have reported the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium (1). The discovery of native cardiobl...