Neonatal and Adult Mice Transient Presence of Anti-Idiotype Antibodies in Bromelain-Treated Mouse Red Blood Cells by a Induction of Tolerance in B-1 Cells for
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Induction of tolerance in B-1 cells for bromelain-treated mouse red blood cells by a transient presence of anti-idiotype antibodies in neonatal and adult mice.
Murine B-1 cells are thought to develop from Ig- progenitors early in ontogeny and to expand by self-renewal. To examine the early development of Ig+ precursors of B-1 cells for bromelain-treated mouse RBC, the transient presence of RidA, a rat anti-Id mAb for V(H)11/Vkappa9-type anti-bromelain-treated mouse Abs, was produced in neonatal mice. The presence of RidA during days 0 to 10 of age res...
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