Glycoprotein I of varicella-zoster virus is required for viral replication in skin and T cells.
نویسندگان
چکیده
Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.
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ورودعنوان ژورنال:
- Journal of virology
دوره 76 16 شماره
صفحات -
تاریخ انتشار 2002