Hydrolysis of choline esters by rabbit liver oligomeric and monomeric carboxylesterases (EC 3.1.1.1).
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چکیده
منابع مشابه
[Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety].
Prodrug is a useful approach for improving the bioavailability of therapeutic agents through increased passive transport. Carboxylesterases (CESs, EC.3.1.1.1.) that show ubiquitous expression profiles play an important role in the biotransformation of ester-containing prodrugs into their therapeutically active forms in the body. High levels of CESs are found in the liver, small intestine and lu...
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Rabbit atropinesterase and cocainesterase were studied by starch gel electrophoresis. The enzymes are localized in a region of the gels anodal to the albumins (prealbumin esterases). In this region, three groups of esterase zones ( S, F, and D) can be distinguished. The S and F zones are almost exclusively responsible for the hydrolysis of cocaine and atropine, respectively. There is an interde...
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A series of substituted trifluoroketones were tested as inhibitors of mammalian liver microsomal carboxylesterase(s) hydrolyzing a variety of substrates including malathion, diethylsuccinate (DES) and p-nitrophenyl acetate (p-NpAc). The trifluoroketones used were very potent "transition state" inhibitors of crude mouse and human liver microsomal carboxylesterases as well as commercial porcine l...
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Aspirin (acetylsalicylic acid) and clopidogrel are two major antithrombogenic agents that are widely used for the treatment and prevention of cerebro- and cardiovascular conditions such as stroke. Combined use produces enhanced therapeutic effect. Aspirin and clopidogrel both are esters, and hydrolysis leads to decreased or inactivated therapeutic activity. The aim of the study was to determine...
متن کاملSubunit weight and N-terminal groups of liver and kidney carboxylesterases (EC 3.1.1.1).
During the past decade considerable progress has been made in the isolation of highly purified carboxylesterases and in the evaluation of their molecular properties (for a review see [ 11). The molecular weight of pig liver esterase, as independently determined by ultracentrifugation in three laboratories, is 163,000-168,000 [2-41. The equivalent weight of unspecific carboxylesterases was estim...
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 255 15 شماره
صفحات -
تاریخ انتشار 1980