Selective inhibition of parallel DNA damage response pathways optimises radiosensitisation of glioblastoma stem-like cells Running title: Radiosensitisation of glioblastoma stem-like cells
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چکیده
Author Contributions Conception and Design: Shafiq U Ahmed, Ross Carruthers, Anthony J Chalmers Development of methodology: Shafiq U Ahmed, Ross Carruthers, Lesley Gilmour, Salih Yildirim Acquisition of data: Shafiq U Ahmed, Ross Carruthers, Lesley Gilmour Analysis of data: Shafiq U Ahmed, Ross Carruthers, Lesley Gilmour Writing/review of manuscript: Shafiq U Ahmed, Colin Watts, Anthony J Chalmers Study supervision: Anthony J Chalmers
منابع مشابه
Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.
Glioblastoma is the most common form of primary brain tumor in adults and is essentially incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor recurrence is inevitable and is thought to be driven by glioblastoma stem-like cells (GSC) that are highly radioresistant. DNA damage response pathways are key determinants of radiosensitivity but the extent to which these over...
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Glioblastoma is themost common formof primary brain tumor in adults and is essentially incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor recurrence is inevitable and is thought to be driven by glioblastoma stem-like cells (GSC) that are highly radioresistant. DNA damage response pathways are key determinants of radiosensitivity but the extent to which these overla...
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