IDENTIFICATION OF THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFI) IN HUMAN PLATELETS Running title: Identification of TAFI in platelets
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Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets.
Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme that after activation down-regulates fibrinolysis. Platelets are known to contain antifibrinolytic factors that are secreted during platelet activation. Therefore, the presence of TAFI in platelets was analyzed. TAFI was identified in platelets in a concentration of about 50 ng/1 x 109 platelets and was se...
متن کاملRegulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis.
The coagulation and fibrinolytic systems safeguard the patency of the vasculature and surrounding tissue. Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. Identification of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation and fibrinolysis, ...
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Title Increase in plasma thrombin-activatable fibrinolysis inhibitor may not contribute to thrombotic tendency in antiphospholipid syndrome because of inhibitory potential of antiphospholipid antibodies toward TAFI activation Author(s) Ieko, Masahiro; Yoshida, Mika; Naito, Sumiyoshi; Nakabayashi, Toru; Kanazawa, Kaoru; Mizukami, Kazuhiro; Mukai, Masaya; Atsumi, Tatsuya; Koike, Takao Citation In...
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INTRODUCTION Recently, we demonstrated that digestive tract cancer (DTC) is associated with reduced fibrin clot permeability and impaired fibrinolysis. AIM We investigated determinants of fibrinolysis in DTC patients. MATERIAL AND METHODS In 44 consecutive patients with DTC and 47 controls matched for age, sex, and cardiovascular risk, we evaluated fibrinolysis proteins, platelet activation...
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OBJECTIVE The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) remains to be elucidated. Thrombin-activatable fibrinolysis inhibitor (TAFI) inhibits fibrinolysis. It remains to be elucidated whether TAFI is directly involved in the pathogenesis of CTEPH. We examined potential involvement of TAFI in the pathogenesis of CTEPH in humans. APPROACH AND RESULTS We enrolled 68 c...
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