Pseudomonas aeruginosa: Multi-Drug-Resistance Development and Treatment Options

Antibiotic resistance is a worldwide problem of major importance. Isolations in some countries of multi-drug-resistant (resistant to three or more classes of antimicrobials), extensively-drug-resistant (resistant to all but one or two classes) or even pan-drugresistant (resistant to all available classes) Gram-negative pathogens are causing therapeu‐ tic problems andin the same timeare posing infection control issues in many hospitals. In fact, numerous studies highlight the link between multi-drug-resistance and increased morbidity and mortality, increased length of hospital stay and higher hospital costs [1-4].