BriefDefinitive Report THE MACROPHAGE RESPONSE TO CENTRAL AND PERIPHERAL NERVE INJURY A Possible Role for Macrophages in Regeneration
نویسندگان
چکیده
Injuries to axons in both the central and peripheral nervous systems (CNS and PNS) of mammals result in axonal degeneration distal to the site of the lesion (Wallerian degeneration) and removal of their surrounding myelin sheaths . In the PNS, myelin is rapidly degraded over a few days or weeks, and the axons regenerate but in the CNS the myelin may persist for months (1, 2), and the axons do not regenerate . We have no explanation for this difference, and there is controversy as to which cells are responsible for the rapid removal of myelin in the PNS (3) . Recent evidence suggests that macrophages (MO) may be important in the removal of myelin from the degenerating peripheral nerve (4) . Using the mAb F4/80 (5), specific for mouse M0, we have examined the contribution of Mo to Wallerian degeneration in the CNS and PNS and considered the possible role they may play in subsequent repair .
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