Improved Analysis of Trace Hormones in Drinking Water by LC/MS/MS (EPA 539) using the Agilent 6460 Triple Quadrupole LC/MS
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چکیده
A modification to the chromatographic conditions of EPA method 539 has been developed that reduces the total run time by more than a factor of three, while providing complete baseline resolution of all seven hormones and DLs that meet the EPA requirements. Response is 7 to 11 times more sensitive in negative mode compared to the use of ammonium hydroxide, and 1.7 to 2.4 times more sensitive in positive mode. The performance of the Agilent 6460 Triple Quadrupole LC/MS System can be used to determine where problems may be occurring, if labs have trouble in method implementation.
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