Antibiogram of Escherichia Coli, Klebsiella Pneumoniae, and Klebsiella Oxytoca from Invasive Disease Cases at a Tertiary Care University Hospital in the Central Region of Japan from 2008 to 2010

This study was conducted to find out the antimicrobial susceptibility characteristics of Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytoca isolated from invasive disease cases at tertiary care university hospital in the central region of Japan from 2008 to 2010. Invasive bacterial disease was defined as isolation of bacteria from a normally sterile body site. Bacteriawere identified by standard laboratory procedure. Antibacterial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Two hundred fifty-seven Escherichia coli, ninety Klebsiella pneumoniae, and sixteen Klebsiella oxytoca were obtained from sterile site for three years. The present study showed that all Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytoca were sensitivity to amikacin. Over 80% of Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytocawere sensitive to ceftazidime, cefepime, aztreonam, and gentamicin. Minocycline is relatively ineffective against Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytocain this study. Although antibiotics resistant Enterobacteriaceae spread worldwide, several antibiotics such as amikacin are still effective against invasive Enterobacteriaceae in Japan. Continuous antimicrobial surveillance is needed for treatment of invasive bacterial disease.