Oncogenicity of Furine 3-Oxide and Unsubstituted Purine in Rats1
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چکیده
Injection s.c. of purine 3-oxide into Wistar rats resulted in the appearance of sarcomas and fibromas at the interscapular site of administration, carcinomas in the liver, and a high incidence of s.c. fibromas in the hip at a distance from the site of injection. A small number of liver tumors but no tumors at the injection site appeared in rats to which the parent compound, purine, was administered. Oxidation of purine 3-oxide by xanthine oxidase was found to occur in two steps to yield the potent oncogen 3hydroxyxanthine. A similar process may occur in vivo since a protein preparation from rat s.c. tissue has similar oxidizing activity.
منابع مشابه
Highly efficient synthesis of carboacyclic nucleosides catalyzed by zinc oxide in 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br)
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