UNRELATED DONOR HEMATOPOIETIC CELL TRANSPLANTATION: MARROW OR UMBILICAL CORD BLOOD? Short title: Donor selection: Bone Marrow or Cord Blood?
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چکیده
منابع مشابه
A Review of Procedures Involved in Human Umbilical Cord Blood Banking and Transplantation
Cord blood hematopoietic stem cells are widely used as an alternative source for hematopoietic stem cells transplant. Increasing rate of patients who need hematopoietic stem cells transplant and many advantages of cord blood in comparison to bone marrow hematopoietic stem cells, have promoted banking of cord blood units. Cord blood banking requires accurate steps in donor selection, cord blood ...
متن کاملDonor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and...
متن کاملUmbilical cord blood transplantation.
Interest in umbilical cord blood as an alternative source of hematopoietic stem cells is growing rapidly. Umbilical cord blood offers the clinician a source of hematopoietic stem cells that are readily available and rarely contaminated by latent viruses. Moreover, the collection of umbilical cord blood poses no risk to the donor; there is no need for general anesthesia or blood replacement, and...
متن کاملRAPID COMMUNICATION Successful Transplantation of HLA-Matched and HLA-Mismatched Umbilical Cord Blood From Unrelated Donors: Analysis of Engraftment and Acute Graft-Versus-Host Disease
To reduce the morbidity and mortality associated with unrelated donor bone marrow (BM) transplantation and potentially extend the pool of suitable donors, cryopreserved unrelated donor umbilical cord blood was considered as an alternate source of hematopoietic stem cells for transplantation. Patients with leukemia, BM failure syndrome, or inborn error of metabolism were eligible for a phase I c...
متن کاملStem Cell Biology in Health and Disease
It took exactly 100 years from the original discovery of the blood for-mation within the bone marrow until the first successful clinical bone marrow transplantation has been performed. Today, the transplantation of hematopoieticstem cells from various sources, such as bone marrow, mobilized stem cells aswell as umbilical cord blood has become a routine procedure, reaching currently<...
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