Immunoglobulin Superantigen Protein L Induces IL-4 and IL-13 Secretion from Human Fc RI Cells Through Interaction with the Light Chains of IgE
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Nasal Mast Cells in Perennial Allergic Rhinitics Exhibit Increased Expression of the Fc e RI, CD40L, IL-4, and IL-13, and Can Induce IgE Synthesis in B Cells
Cross-linking of allergen specific IgE bound to the high affinity IgE receptor (Fc e RI) on the surface of mast cells with multivalent allergens results in the release of both preformed and newly generated mediators, and in the manifestation of allergic symptoms. The expression of Fc e RI, and the synthesis of IgE are therefore critical for the development of allergic diseases. In this study, w...
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A population of cells that express mast cell markers, including the membrane protein p161, but that lack expression of the high affinity IgE receptor, Fc epsilon RI, can be routinely grown from bone marrow. Ionomycin, but not IgE immune complexes, causes these cells to release serotonin and to express IL-3 and IL-13 mRNA, consistent with their being FC epsilon RI-deficient mast cells. These p16...
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