*Running title: Role of HTRA1 in intervertebral disc degeneration
نویسندگان
چکیده
From the Bone and Stem Cell Research Group, CABMM, University of Zurich, 8057 Zurich, Switzerland, Spine Research Group, CABMM, University of Zurich, 8057 Zurich, Switzerland, Centre for Medical Biotechnology, Faculty of Biology and Geography, University Duisburg-Essen, 45117 Essen, Germany, Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland, Department of Spinal Surgery, SRH Klinikum KarlsbadLangensteinbach, Karlsbad, Germany, AOSpine Research Network, 8600 Duebendorf, Switzerland .
منابع مشابه
Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine intervertebral disc organ culture model.
STUDY DESIGN In vitro study to develop an intervertebral disc degeneration organ culture model, using coccygeal bovine intervertebral discs (IVDs) and injection of proteolytic enzymes MMP-3, ADAMTS-4, and HTRA1. OBJECTIVE This study aimed to develop an in vitro model of enzyme-mediated intervertebral disc degeneration to mimic the clinical outcome in humans for investigation of therapeutic tr...
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