ANCA Associated Glomerulonephritis- An In-Depth Review

Inflammation of vasculature involving small to medium vessels associated with antineutrophil cytoplasmic antibodies or ANCA are collectively referred to as ANCA vasculitidis. In a majority of such disorders there are a few or no immune deposits and hence the term“pauci immune vasculitis”. The three main conditions included in this group include microscopic polyangiitis, Granulomatosis with polyangiitis (GPA) formerly known as Wegener’s granulomatosis, and Eosinophilic Granulomatosis with Polyangiitis (EGPA)-formerly known as Churg-Strauss Syndrome. There have been several advances in the last two decades in the classification, understanding of the pathogenesis and management of these conditions. To provide an update on the classification, pathology and pathogenesis and therapeutic advances for management of ANCA vasculitis is the focus of this in depth review. *Corresponding author: Sharma S Prabhakar, FACP FASN Professor and Chief, Division of Nephrology Vice-Chairman, Department of Medicine, Texas Tech University Health Sciences Center, Room 4B071 3601 4th Street STOP 9410, Lubbock, Texas 79430-6271, Tel: 806.743.3155 ext 252; Fax: 806.743.3148; E-mail: [email protected] Received September 01, 2013; Accepted December 24, 2013; Published December 27, 2013 Citation: Kaldas A, Warraich I, Prabhakar SS (2013) ANCA Associated GlomerulonephritisAn In-Depth Review. J Nephrol Ther 4: 147. doi:10.4172/21610959.1000147 Copyright: © 2013 Kaldas A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.