Solid Phase Extraction : A Chromatographic Perspective

Consider how these problems could be solved by using a solid phase (such as a chromatographic sorbent) instead of the second liquid phase. There are still two distinct phases that can be readily segregated. Also, by proper selection of pH and type of solid phase sorbent, one could optimize the conditions to selectively partition the component(s) of interest on the solid phase. After removal of the liquid phase, a second liquid phase could be employed to desorb these components. As in the case of LLE, a second liquid-solid extraction may be required.