The Mycoplasma conjunctivae annotation and analysis

Mycoplasmas (class Mollicutes) are among the smallest microorganisms capable of self and autonomous life (1). The genus Mycoplasma includes a large number reduced species which in nature are associated with hosts either commensally or pathogenically General features of the class Mollicutes are small genome, lack of cell wall and low GC content. Indeed, the Mycoplasma species Woese CR et al. (1980) revealed that firmicutes taxon by a so-called regressive evolution that resulted in mass 5) and a minimal metabolic activities. Consequently, they a occurring as extracellular parasites often restricted to a living host, with so ability to invade host cells as described by Rosengarten R 7). They have a predilection for the with many other organisms, esta factor as known in other bacteria, instead of they secrete and translocate to host cells as virulence factors wall, they are not affected by s other beta-lactam antibiotics making these organisms partic Mycoplasma conjunctivae is considered as the major etiological KeratoConjunctivitis (IKC) for both domestic and wild Caprinae species affects several species such as alpine ibex (rupicapra), and mouflon (Ovis orientalis Switzerland, M. conjunctivae is known to be the primary cause of this disease Figure 2. Alpine Ibex / " Bouquetin " (Capra ibex ibex) The implied role of M.conjunctivae eyes and on limited attempts to induce ocular disease experimentally that have showed that conjunctivae is one agent responsible for epidemic keratoconjunctivitis molecular epidemiology has been well described by Belloy L mechanism is still not established and remains a mystery. 2. Infectious keratoconjunctivitis (IKC) disease Infectious keratoconjunctivitis (IKC) is a contagious ocular known as « pinkeye » and wild Caprinae animals. the conjunctiva and cornea. In the most resulting in blind wild animals fall Figure 5. " Pink eye " in sheep Introduction 3 The disease is known to be endemic in the Swiss sheep population showing a high prevalence of M. conjunctivae antibodies in adult sheep at the individual level. Hence, the domestic sheep population acts as a reservoir of the M. conjunctivae infection (8; 11). In contrast, the M. conjunctivae infection is not self maintained in alpine chamois in eastern Switzerland (20). Their infection may originate from domestic sheep living in proximity to chamois during the summer as Giacometti, L. et al. (2002) demonstrated in their paper " Mycoplasma conjunctivae Infection is not maintained in Alpine Chamois in Eastern Switzerland " (11). Another hypothesis suggests that the transmission of M. conjunctivae …