Radioiron Incorporation by a Transplantable Lymphoid Tumor1
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چکیده
revealed little or no hemosiderin in the tumor or bone marrow but revealed moderate to marked increases in the amount of hemosiderin in the spleen and liver of most of the chickens that were inoculated with tumor. Lymphoid tumor-bearing chickens developed a progressive hypoferremia, and there was a precipitous drop in the packed cell volume. An increase occurred in both serum iron-binding capacity and transferrin levels over a 12-day period following tumor implantation. The uptake of iron by transplantable lymphoid tumor cells and an apparent blockage of iron reutilization were responsible for the rapid decline in serum iron. healthy adult volunteers lacked this capacity. These findings indicate that tumor cells have an essential requirement for iron and suggest that such cells may serve as iron traps, thereby contributing to the hypoferremia of cancer. We investigated this hypothesis by examining the ability of cells of a chicken TLT (30) to incorporate radioiron. Chickens inoculated with this transplantable tumor (Olson) develop a progressive anemia and may serve as useful models for the study of cancer-associated anemia (8). The tissue quantitation and autoradiographic demonstration of the in vivo incorporation of radioiron by these lymphoid tumor cells from 59Fe-labeled
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تاریخ انتشار 2006