Identification and Sequence Analysis of Two New Members of the SKALP/elafin and SPAI-2 Gene Family BIOCHEMICAL PROPERTIES OF THE TRANSGLUTAMINASE SUBSTRATE MOTIF AND SUGGESTIONS

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  • Patrick L. J. M. Zeeuwen
  • Wiljan Hendriks
چکیده

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Identification and sequence analysis of two new members of the SKALP/elafin and SPAI-2 gene family. Biochemical properties of the transglutaminase substrate motif and suggestions for a new nomenclature.

The human epithelial proteinase inhibitor SKALP/elafin and the porcine sodium-potassium ATPase inhibitor SPAI-2 are two highly homologous proteins that share an NH2-terminal transglutaminase substrate domain and a COOH-terminal whey acidic protein (WAP) domain. Here we describe the bovine and simian orthologs of SKALP/elafin as well as two new bovine family members that are designated Trappin-4...

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تاریخ انتشار 2017