Pii: S0378-1119(02)00678-9
نویسندگان
چکیده
A novel 72 nt small nucleolar RNA (snoRNA) called U87 was found in rat liver cells. This RNA possesses the features of C/D box snoRNA family: boxes C, D 0, C 0, D, and 11 nt antisense element complementary to 28S ribosomal RNA (rRNA). The vast majority of C/D box snoRNAs direct site-specific 2 0-O-ribose methylation of rRNAs. U87 RNA is suggested to be involved in 2 0-O-methylation of a G3468 residue in 28S rRNA. U87 RNA was detected in different mammalian species with slight length variability. Rat and mouse U87 RNA gene was characterized. Unlike the majority of C/D box snoRNAs U87 RNA lacks the terminal stem required for snoRNA processing. However, U87 gene is flanked by 7 bp inverted repeats potentially able to form a terminal stem in U87 RNA precursor. q 2002 Elsevier Science B.V. All rights reserved.
منابع مشابه
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